Electrochemotherapy for cutaneous and subcutaneous tumor lesions: a novel therapeutic approach
Identifieur interne : 005D29 ( Main/Exploration ); précédent : 005D28; suivant : 005D30Electrochemotherapy for cutaneous and subcutaneous tumor lesions: a novel therapeutic approach
Auteurs : Alessandro Testori [Italie] ; Giulio Tosti [Italie] ; Chiara Martinoli [Italie] ; Giuseppe Spadola [Italie] ; Francesco Cataldo [Italie] ; Francesco Verrecchia [Italie] ; Federica Baldini [Italie] ; Massimo Mosconi [Italie] ; Javier Soteldo [Italie] ; Ines Tedeschi [Italie] ; Claudia Passoni [Italie] ; Chiara Pari [Italie] ; Alessandra Di Pietro [Italie] ; Pier Francesco Ferrucci [Italie]Source :
- Dermatologic Therapy [ 1396-0296 ] ; 2010-11.
Abstract
Electroporation uses pulsed, high‐intensity electric fields to temporarily increase cell membrane permeability by creation of pores, through which small molecules, such as chemotherapeutic agents, can diffuse inside cells before they reseal. The combination of electroporation with the administration of otherwise low‐permeant cytotoxic drugs is known as electrochemotherapy (ECT). The two most commonly used drugs are bleomycin and cisplatin. ECT has already been proven to be effective in diverse tumor histotypes, including melanoma and basal and squamous cell carcinoma, Kaposi sarcoma, and breast cancer, also in those cases nonresponding to classical chemotherapies or other loco‐regional treatment modalities, with a good safety profile. ECT can be proposed as loco‐regional therapy for disseminated cutaneous and subcutaneous tumor lesions as alternative treatment modality to conventional therapies or as palliative care, in order to improve patients' quality of life.
Url:
DOI: 10.1111/j.1529-8019.2010.01370.x
Affiliations:
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sortKey="Di Pietro, Alessandra" sort="Di Pietro, Alessandra" uniqKey="Di Pietro A" first="Alessandra" last="Di Pietro">Alessandra Di Pietro</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Melanoma and Muscle‐Cutaneous Sarcoma Division, European Institute of Oncology, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Ferrucci, Pier Francesco" sort="Ferrucci, Pier Francesco" uniqKey="Ferrucci P" first="Pier Francesco" last="Ferrucci">Pier Francesco Ferrucci</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Melanoma and Muscle‐Cutaneous Sarcoma Division, European Institute of Oncology, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Dermatologic Therapy</title><title level="j" type="alt">DERMATOLOGIC THERAPY</title><idno type="ISSN">1396-0296</idno><idno type="eISSN">1529-8019</idno><imprint><biblScope unit="vol">23</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="651">651</biblScope><biblScope unit="page" to="661">661</biblScope><biblScope unit="page-count">11</biblScope><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2010-11">2010-11</date></imprint><idno type="ISSN">1396-0296</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1396-0296</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Electroporation uses pulsed, high‐intensity electric fields to temporarily increase cell membrane permeability by creation of pores, through which small molecules, such as chemotherapeutic agents, can diffuse inside cells before they reseal. The combination of electroporation with the administration of otherwise low‐permeant cytotoxic drugs is known as electrochemotherapy (ECT). The two most commonly used drugs are bleomycin and cisplatin. ECT has already been proven to be effective in diverse tumor histotypes, including melanoma and basal and squamous cell carcinoma, Kaposi sarcoma, and breast cancer, also in those cases nonresponding to classical chemotherapies or other loco‐regional treatment modalities, with a good safety profile. ECT can be proposed as loco‐regional therapy for disseminated cutaneous and subcutaneous tumor lesions as alternative treatment modality to conventional therapies or as palliative care, in order to improve patients' quality of life.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><country name="Italie"><region name="Lombardie"><name sortKey="Testori, Alessandro" sort="Testori, Alessandro" uniqKey="Testori A" first="Alessandro" last="Testori">Alessandro Testori</name></region><name sortKey="Baldini, Federica" sort="Baldini, Federica" uniqKey="Baldini F" first="Federica" last="Baldini">Federica Baldini</name><name sortKey="Cataldo, Francesco" sort="Cataldo, Francesco" uniqKey="Cataldo F" first="Francesco" last="Cataldo">Francesco Cataldo</name><name sortKey="Di Pietro, Alessandra" sort="Di Pietro, Alessandra" uniqKey="Di Pietro A" first="Alessandra" last="Di Pietro">Alessandra Di Pietro</name><name sortKey="Ferrucci, Pier Francesco" sort="Ferrucci, Pier Francesco" uniqKey="Ferrucci P" first="Pier Francesco" last="Ferrucci">Pier Francesco Ferrucci</name><name sortKey="Martinoli, Chiara" sort="Martinoli, Chiara" uniqKey="Martinoli C" first="Chiara" last="Martinoli">Chiara Martinoli</name><name sortKey="Mosconi, Massimo" sort="Mosconi, Massimo" uniqKey="Mosconi M" first="Massimo" last="Mosconi">Massimo Mosconi</name><name sortKey="Pari, Chiara" sort="Pari, Chiara" uniqKey="Pari C" first="Chiara" last="Pari">Chiara Pari</name><name sortKey="Passoni, Claudia" sort="Passoni, Claudia" uniqKey="Passoni C" first="Claudia" last="Passoni">Claudia Passoni</name><name sortKey="Soteldo, Javier" sort="Soteldo, Javier" uniqKey="Soteldo J" first="Javier" last="Soteldo">Javier Soteldo</name><name sortKey="Spadola, Giuseppe" sort="Spadola, Giuseppe" uniqKey="Spadola G" first="Giuseppe" last="Spadola">Giuseppe Spadola</name><name sortKey="Tedeschi, Ines" sort="Tedeschi, Ines" uniqKey="Tedeschi I" first="Ines" last="Tedeschi">Ines Tedeschi</name><name sortKey="Tosti, Giulio" sort="Tosti, Giulio" uniqKey="Tosti G" first="Giulio" last="Tosti">Giulio Tosti</name><name sortKey="Verrecchia, Francesco" sort="Verrecchia, Francesco" uniqKey="Verrecchia F" first="Francesco" last="Verrecchia">Francesco Verrecchia</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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